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Disclosures: Prabhu Ponnandy: Nothing to Disclose, Chinmay Raut: Nothing to Disclose, Rawdat Hussain: Nothing to Disclose, Akram Irshaid: Nothing to Disclose, Brian Halligan: Nothing to Disclose, Elizabeth Speliotes: Nothing to Disclose 2559 METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE ASSOCIATED ALLELE GCKR (P446L) PROMOTES FGF21 SECRETION VIA UP-REGULATING TRANSCRIPTION FACTOR CHREBP IN HUH-7 CELL LINE Yue Chen 1 Rawdat Hussain 1 Jason Chen 2 Antonio Oliveri 1 Brian Halligan 1 Elizabeth Speliotes 1 , 1 University of Michigan Medical Center, 2 Judd A